PD-L1hi B cells are critical regulators of humoral immunity

Academic Article

Abstract

  • © 2015 Macmillan Publishers Limited. All rights reserved. Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However, Breg cell mediated immune suppression, independent of IL-10, also occurs. Here we show that Breg cells play a critical role in regulating humoral immunity mediated by CD4+CXCR5+PD-1+ follicular helper T cells, and can suppress inflammation in autoimmune disease through elevated expression of PD-L1. We have also identified that these B cells are resistant to αCD20 B-cell depletion. This work describes how Breg cells are critical in humoral homoeostasis and may have implications for the regulation of autoimmune diseases.
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    Author List

  • Khan AR; Hams E; Floudas A; Sparwasser T; Weaver CT; Fallon PG
  • Volume

  • 6