Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection

Academic Article

Abstract

  • © 2015 Glennie et al. Leishmaniasis causes a significant disease burden worldwide. Although Leishmania-infected patients become refractory to reinfection after disease resolution, effective immune protection has not yet been achieved by human vaccines. Although circulating Leishmaniaspecific T cells are known to play a critical role in immunity, the role of memory T cells present in peripheral tissues has not been explored. Here, we identify a population of skinresident Leishmania-specific memory CD4+ T cells. These cells produce IFN-γ and remain resident in the skin when transplanted by skin graft onto naive mice. They function to recruit circulating T cells to the skin in a CXCR3-dependent manner, resulting in better control of the parasites. Our findings are the first to demonstrate that CD4+ TRM cells form in response to a parasitic infection, and indicate that optimal protective immunity to Leishmania, and thus the success of a vaccine, may depend on generating both circulating and skinresident memory T cells.
  • Digital Object Identifier (doi)

    Author List

  • Glennie ND; Yeramilli VA; Beiting DP; Volk SW; Weaver CT; Scott P
  • Start Page

  • 1405
  • End Page

  • 1414
  • Volume

  • 212
  • Issue

  • 9