Duality in the Th17-Treg developmental decision.

Academic Article

Abstract

  • Each of the effector CD4 T-cell lineages - Th1, Th2, and the more recently identified Th17 - arises from pluripotent na├»ve precursors whose developmental fate is largely controlled by cytokines that act in concert with antigenic signals. Remarkably, development of the Th17 lineage has been linked to that of regulatory T cells, which obviate or downregulate Th17 responses to preserve immune homeostasis, through a shared requirement for the cytokine transforming growth factor-beta. Several new studies offer insights into the mechanism whereby the precursors of these subsets are directed into distinct lineages.
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    Digital Object Identifier (doi)

    Author List

  • Hatton RD; Weaver CT
  • Start Page

  • 5
  • Volume

  • 1