Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic Bacteria

Academic Article

Abstract

  • Interleukin-22 (IL-22) is central to host protection against bacterial infections at barrier sites. Both innate lymphoid cells (ILCs) and T cells produce IL-22. However, the specific contributions of CD4+ T cells and their developmental origins are unclear. We found that the enteric pathogen Citrobacter rodentium induced sequential waves of IL-22-producing ILCs and CD4+ T cells that were each critical to host defense during a primary infection. Whereas IL-22 production by ILCs was strictly IL-23 dependent, development of IL-22-producing CD4+ T cells occurred via an IL-6-dependent mechanism that was augmented by, but not dependent on, IL-23 and was dependent on both transcription factors T-bet and AhR. Transfer of CD4+ T cells differentiated with IL-6 in the absence of TGF-β (" Th22" cells) conferred complete protection of infected IL-22-deficient mice whereas transferred Th17 cells did not. These findings establish Th22 cells as an important component of mucosal antimicrobial host defense. © 2012 Elsevier Inc.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Basu R; O'Quinn DB; Silberger DJ; Schoeb TR; Fouser L; Ouyang W; Hatton RD; Weaver CT
  • Start Page

  • 1061
  • End Page

  • 1075
  • Volume

  • 37
  • Issue

  • 6