A vital role for Interleukin-21 in the control of a chronic viral infection

Academic Article

Abstract

  • Understanding the factors that regulate the induction, quality, and longevity of antiviral T cell responses is essential for devising rational strategies to prevent or combat infections. In this study, we show that interleukin-21 (IL-21), likely produced by CD4+ T cells, directly influences the generation of polyfunctional CD8+ T cells and that the number of CD4+ T cells that produce IL-21 differs markedly between acute and chronic infections. IL-21 regulates the development of CD8+ T cell exhaustion and the ability to contain chronic lymphocytic choriomeningitis virus infection. Thus, IL-21 serves as a critical helper factor that shapes the functional quality of antiviral CD8+ T cells and is required for viral control.
  • Digital Object Identifier (doi)

    Author List

  • Yi JS; Du M; Zajac AJ
  • Start Page

  • 1572
  • End Page

  • 1576
  • Volume

  • 324
  • Issue

  • 5934