Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy.

Academic Article


  • In infants with hypoxic-ischemic encephalopathy, cooling reduces death/neurodevelopmental impairment, whereas prophylactic anticonvulsants may not. This retrospective analysis shows no reduction in neurodevelopmental impairment (23% in prophylactic phenobarbital group vs 45% in controls, P = .3) but fewer clinical seizures in cooled infants who received prophylactic phenobarbital (15% vs 82% P < .0001).
  • Published In


  • Anticonvulsants, Child, Preschool, Cold Temperature, Excitatory Amino Acid Antagonists, Female, Humans, Hydrogen-Ion Concentration, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Male, Phenobarbital, Retrospective Studies, Temperature, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Meyn DF; Ness J; Ambalavanan N; Carlo WA
  • Start Page

  • 334
  • End Page

  • 336
  • Volume

  • 157
  • Issue

  • 2