Effect of adenine arabinoside on cytomegalovirus infections

Academic Article

Abstract

  • Twelve of 17 patients with cytomegalovirus infections (two with mononucleosis, five with disseminated infection and immunosuppression, and five congenitally infected infants) were treated with 5-20 mg of adenine arabinoside (ara A)/kg intravenously for six to 18 days. Infants and patients with mononucleosis had higher titers of cytomegalovirus in urine before treatment and more prolonged urinary viral suppression after treatment than immunosuppressed patients. However, a quantitatively lesser viruria returned after one to three weeks in all patients. During therapy in immunosuppressed patients, urinary excretion of cytomegalovirus was only slightly reduced, with persistent viremia. Clinically, two infants and two patients with mononucleosis improved; immunosuppressed patients did not improve. No significant clinical toxicity to the liver, kidney, or bone marrow occurred in the patients treated. An untreated group of three immunosuppressed patients and two with mononucleosis had persistent viremia and viruria. The results suggest that a subtoxic dosage of ara A suppresses urinary excretion of cytomegalovirus in man. The poor response in immunosuppressed patients may be due to the severity of immunosuppression, individual variation in metabolism of ara A, the presence of concurrent infections, or possibly, specificity of cytomegalovirus strains. (14 references.)
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ch'ien LT; Cannon NJ; Whitley RJ; Diethelm AG; Dismukes WE; Scott CW; Buchanan RA; Alford CA
  • Start Page

  • 32
  • End Page

  • 39
  • Volume

  • 130
  • Issue

  • 1