Structural and biophysical characterization of the interactions between the death domain of fas receptor and calmodulin

Academic Article

Abstract

  • Background: Calmodulin (CaM) is recruited into the death-inducing signaling complex in cholangiocarcinoma cells. Results: CaM binds to FasDD in a 2:1 CaM:FasDD model. CaM antagonists abolish FasDD-CaM interactions. Conclusion: Data offer a structural basis for Fas-CaM interactions and mechanisms of inhibition. Significance: Elucidating the structural determinants of Fas-CaM interaction is critical to understanding the functional role of CaM in Fas-mediated apoptosis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Fernandez TF; Samal AB; Bedwell GJ; Chen Y; Saad JS
  • Start Page

  • 21898
  • End Page

  • 21908
  • Volume

  • 288
  • Issue

  • 30