Discovery of streptococcus pneumoniae serotype 6 variants with glycosyltransferases synthesizing two differing repeating units

Academic Article


  • Background: Two atypical serogroup 6 strains have been discovered. Results: They express capsular polysaccharide with two different repeating units and share A150T mutation in WciN. Conclusion: This mutation shifts WciN from a galactosyltransferase to a bi-specific glycosyltransferase, creating two new hybrid serotypes: 6F and 6G. Significance: Pneumococci can change capsule serotypes by point mutations and may alter their interactions with the immunity of the host. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Oliver MB; Van Der Linden MPG; Küntzel SA; Saad JS; Nahm MH
  • Start Page

  • 25976
  • End Page

  • 25985
  • Volume

  • 288
  • Issue

  • 36