The impact of neuropsychological performance on everyday functioning between older and younger adults with and without HIV.

Academic Article


  • In this cross-sectional study, a community-based sample of 162 younger and older adults with and without HIV was compared on neuropsychological and everyday-functioning measures. In the HIV sample, the relationship between cognition, everyday functioning, and HIV biomarkers was also examined. A battery of cognitive tests was completed along with two laboratory measures of everyday functioning and one measure of HIV medication adherence. Main effects for age and HIV were found on several neuropsychological measures and on the Timed Instrumental Activities of Daily Living test; those who were older or who had HIV exhibited poorer performance. Although age-by-HIV interactions were not observed, older adults with HIV as a group performed worse on eight out of the nine neuropsychological and everyday functioning measures. Few of these neuropsychological and everyday measures were related to HIV biomarkers (e.g., CD4+ T cell count). Implications for nursing practice and research are posited.
  • Keywords

  • Activities of Daily Living, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Anti-Retroviral Agents, CD4-Positive T-Lymphocytes, Case-Control Studies, Cognition, Cognition Disorders, Cross-Sectional Studies, Female, HIV Infections, Humans, Male, Medication Adherence, Memory, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Socioeconomic Factors, Surveys and Questionnaires, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Vance DE; Fazeli PL; Gakumo CA
  • Start Page

  • 112
  • End Page

  • 125
  • Volume

  • 24
  • Issue

  • 2