Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes

Academic Article

Abstract

  • Background: IgA1-producing cells of IgA nephropathy patients secrete IgA1 with galactose-deficientO-glycans; these IgA1 molecules form nephritogenic immune complexes. Results: Cytokines IL-6 and IL-4 accentuate IgA1 galactose deficiency via modulation of key glycosyltransferases. Conclusion: Some cytokines alter IgA1 O-glycosylation and increase production of nephritogenic IgA1 glycoforms. Significance: These data provide a mechanism explaining increased immune-complex formation in IgA nephropathy patients. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Suzuki H; Raska M; Yamada K; Moldoveanu Z; Julian BA; Wyatt RJ; Tomino Y; Gharavi AG; Novak J
  • Start Page

  • 5330
  • End Page

  • 5339
  • Volume

  • 289
  • Issue

  • 8