Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus

Academic Article

Abstract

  • Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses. © 2009 Elsevier Inc. All rights reserved.
  • Published In

  • Immunity  Journal
  • Digital Object Identifier (doi)

    Author List

  • Wojciechowski W; Harris DP; Sprague F; Mousseau B; Makris M; Kusser K; Honjo T; Mohrs K; Mohrs M; Randall T
  • Start Page

  • 421
  • End Page

  • 433
  • Volume

  • 30
  • Issue

  • 3