Development of the mouse B-cell repertoire.

Academic Article

Abstract

  • The mouse B-cell repertoire early in ontogeny contains B cells with receptor immunoglobulins exhibiting high connectivity, multi/self-reactivity, and generally low affinity. This is due structurally to extensive restriction in the germline components used to generate the B-cell receptor. The selective pressure acting on the nascent repetoire has both negative and positive components as seen in our in vivo models. VH81X-bearing B cells from the VH81X transgenic mice (and probably from normal mice) are subject to self-selective pressure with two components: a positive one favoring a certain (self-reactive) specificity in the CD23-IgM+ population and a negative one preventing the entry of B cells with this specificity into the CD23+IgM+ compartment.
  • Keywords

  • Animals, Animals, Newborn, Antibody Diversity, B-Lymphocytes, Base Sequence, Clonal Deletion, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Genes, Immunoglobulin, Immune System, Immunoglobulin Heavy Chains, Immunoglobulin Variable Region, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Sequence Alignment, Sequence Homology
  • Author List

  • Martin F; Chen X; Shu F; Kearney JF
  • Start Page

  • 207
  • End Page

  • 221
  • Volume

  • 764