Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells.

Academic Article

Abstract

  • The early involvement of marginal zone (MZ) B lymphocytes in T-independent immune responses is well established. In this study we compared the abilities of MZ and follicular (FO) B cells to collaborate with T cells. After immunization with soluble hen egg lysozyme, both MZ and FO B cells captured Ag and migrated to T cell areas in the response to hen egg lysozyme. MZ B cells were far superior to FO B cells in inducing CD4+ T cell expansion both in vitro and in vivo. MZ, but not FO, B cells, after interaction with T cells, differentiated into plasma cells, and in addition they stimulated Ag-specific CD4+ T cells to produce high levels of Th1-like cytokines upon primary stimulation in vitro. These results indicate that MZ B cells rapidly and effectively capture soluble Ag and activate CD4+ T cells to become effector T cells. The enhanced capacity of MZ B cells to prime T cells in this study appeared to be intrinsic to MZ B cells, as both MZ and FO B cell populations express an identical Ag receptor.
  • Published In

    Keywords

  • Animals, Antigen Presentation, Antigens, CD, B-Lymphocyte Subsets, B7-1 Antigen, B7-2 Antigen, CD4-Positive T-Lymphocytes, Cell Differentiation, Cell Division, Cell Movement, Cells, Cultured, Clone Cells, Cytokines, Dendritic Cells, Endocytosis, Epitopes, T-Lymphocyte, Interphase, Lymphocyte Activation, Lymphocyte Cooperation, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Plasma Cells, Spleen, Th1 Cells
  • Pubmed Id

  • 20423923
  • Author List

  • Attanavanich K; Kearney JF
  • Start Page

  • 803
  • End Page

  • 811
  • Volume

  • 172
  • Issue

  • 2