Regulation of B-cell activation by CD45: a question of mechanism

Academic Article

Abstract

  • Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function? © 1994.
  • Published In

  • Immunology Today  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 19542039
  • Author List

  • Justement LB; Brown VK; Lin J
  • Start Page

  • 399
  • End Page

  • 406
  • Volume

  • 15
  • Issue

  • 9