Identification of polymorphisms in the constant region of IgG3: the missing mouse allotype.

Academic Article

Abstract

  • We have identified DNA sequence polymorphisms in the C gamma 3 genes of BALB/c and C57BL/6 mice. One of these results in a Ser-->Gly amino acid difference in CH1 at position 129 according to the Wu and Kabat numbering system. There are three additional silent substitutions in the coding region and two polymorphic nucleotides in the 3' untranslated region. According to standard nomenclature in which alleles are numbered according to the order of their identification, these C gamma 3 alleles are designated Igh-8a and Igh-8b respectively. We also describe two polymerase chain reaction-based assays that identify the allelic differences.
  • Authors

    Published In

    Keywords

  • Alleles, Amino Acid Sequence, Animals, Base Sequence, Immunoglobulin Allotypes, Immunoglobulin Constant Regions, Immunoglobulin G, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Polymorphism, Genetic
  • Pubmed Id

  • 2253831
  • Authorlist

  • Sun L; Luce MJ; Ren K; Ha H; Burrows PD
  • Start Page

  • 337
  • End Page

  • 341
  • Volume

  • 7
  • Issue

  • 2