B cells are generated throughout life in humans

Academic Article


  • This analysis of B cell development as a function of age reveals a relatively widespread distribution of progenitor B (pro-B), pre-B, and B cells in fetal tissues, and thus supports the idea of a multifocal origin of B lineage cells during embryonic development. From mid-gestation onward, the bone marrow is the major site of B cell generation in humans. A relatively constant ratio of bone marrow precursors to B cells of immature phenotype (CD24(high)CD10+CD20(low)IgD-) is maintained from mid-gestation through the eighth decade of life. The persistence of recombinase gene activity in pro-B cells further attests the sustained production of B cells in bone marrow. Interestingly, a subpopulation of B cells with mature phenotype (CD24(low)CD10-CD20(high)IgD+) accumulates in the bone marrow during childhood, and this becomes the predominant B cell subpopulation in adult bone marrow. This mature population of bone marrow B cells may represent a subpopulation of recirculating B cells that have undergone selection in the periphery.
  • Authors

    Published In

    Pubmed Id

  • 8517568
  • Author List

  • Nuñez C; Nishimoto N; Gartland GL; Billips LG; Burrows PD; Kubagawa H; Cooper MD
  • Start Page

  • 866
  • End Page

  • 872
  • Volume

  • 156
  • Issue

  • 2