B cell development and differentiation.

Academic Article

Abstract

  • The initial phases of B cell development depend on interactions between the cell surface molecules and secreted products of stromal cells with their receptor-ligand partners on lymphoid progenitors. Recent research in this area has greatly advanced our understanding of B cell development and differentiation. Antigen receptors on pre-B and B cells play key roles in the progression of this differentiation process, as revealed by targeted and inherited gene mutations that disrupt B cell development and by the transgenic repair of these mutations in mice.
  • Authors

    Published In

    Keywords

  • Animals, B-Lymphocytes, Cell Differentiation, Humans, Leukopoiesis, Mice
  • Author List

  • Burrows PD; Cooper MD
  • Start Page

  • 239
  • End Page

  • 244
  • Volume

  • 9
  • Issue

  • 2