The transient expression of pre-B cell receptors governs B cell development.

Academic Article

Abstract

  • Only a subpopulation of relatively large pre-B cells express pre-B cell receptors (preBCR) that can be seen with very sensitive immunofluorescence methods. Inefficient assembly of the multicomponent preBCR coupled with their ligand-induced endocytosis may account for the remarkably low in vivo levels of preBCR expression. Signaling initiated via the preBCR promotes cellular proliferation and RAG-1 and RAG-2 downregulation to interrupt the immunoglobulin V(D)J gene rearrangement process. Silencing of the surrogate light chain genes, VpreB and lambda5, then terminates preBCR expression to permit cell cycle exit, recombinase gene upregulation, and VJ(L) rearrangement by small pre-B cells destined to become B cells.
  • Authors

    Published In

    Keywords

  • Animals, B-Lymphocytes, Cell Differentiation, Gene Expression Regulation, Developmental, Gene Rearrangement, B-Lymphocyte, Gene Silencing, Humans, Immunoglobulin Light Chains, Immunoglobulin Light Chains, Surrogate, Membrane Glycoproteins, Pre-B Cell Receptors, Receptors, Antigen, B-Cell, Time Factors
  • Pubmed Id

  • 4074724
  • Author List

  • Burrows PD; Stephan RP; Wang Y-H; Lassoued K; Zhang Z; Cooper MD
  • Start Page

  • 343
  • End Page

  • 349
  • Volume

  • 14
  • Issue

  • 5