Differential expression of FCRLA in naïve and activated mouse B cells

Academic Article

Abstract

  • FCRLA is an intracellular B cell protein that belongs to the FcR-like family. Using newly generated FCRLA-specific antibodies, we studied the constitutive expression pattern of mouse FCRLA and monitored changes during an immune response and following in vitro B cell activation. All B cell subpopulations examined expressed FCRLA. However, the level of FCRLA expression is determined by the stage of B cell differentiation. Low expression of FCRLA is characteristic of naïve follicular and marginal zone B cells. High expression was detected in a small fraction of activated B cells scattered along migratory pathways in the lymphoid tissues. FCRLA-bright cells could be subdivided into two subpopulations, with high and low/undetectable level of intracellular immunoglobulins, which phenotypically resemble either plasma or memory B cells. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion. © 2011 Elsevier Inc.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 8951366
  • Author List

  • Reshetnikova ES; Mechetina LV; Volkova OY; Guselnikov SV; Chikaev NA; Kövesdi D; Alabyev B; Sármay G; Burrows PD; Najakshin AM
  • Start Page

  • 182
  • End Page

  • 192
  • Volume

  • 272
  • Issue

  • 2