Analysis of the diversity of murine antibodies to dextran B1355. II. Demonstration of multiple idiotypes with variable expression in several strains

Academic Article


  • The authors developed radioimmunoassays that detect idiotypic (variable region) differences among the α(1→3) dextran-binding myeloma proteins U102, J558, and M104 as well as an assay that detects variable region determinants common to all three proteins. Using these assays, the authors have examined 7S and 19S anti-α(1→3) dextran antibodies induced in five murine strains of the a1 I(g)C(H) linkage group and the recombinant strain BAB/14. All idiotypes were expressed in both 19S and 7S antibodies from all strains, but with considerable strain-specific variability in penetrance. In two strains, one additional type of antibody, which lacked all four idiotypic determinants, generally constituted the bulk of total anti-α(1→3) dextran antibodies.
  • Authors

    Published In

    Pubmed Id

  • 7470938
  • Author List

  • Hansburg D; Briles DE; Davie JM
  • Start Page

  • 1406
  • End Page

  • 1412
  • Volume

  • 119
  • Issue

  • 4