Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae.

Academic Article

Abstract

  • The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make anti-PC antibody, as a result of suppression with anti-T-15 idiotype or inheritance of the xid gene of CAB/N mice, are highly susceptible to infection with strain WU2. Mice inheriting the xid gene can be protected with NMS from immunologically normal mice or with IgM hybridoma anti-PC antibody. The protective effect of NMS can be removed with PC-containing immunoabsorbents.
  • Published In

    Keywords

  • Animals, Antibodies, Antibody Formation, Antibody Specificity, Choline, Crosses, Genetic, Female, Hybrid Cells, Injections, Intravenous, Male, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Inbred DBA, Phosphorylcholine, Pneumococcal Infections, Streptococcus pneumoniae
  • Pubmed Id

  • 1761701
  • Author List

  • Briles DE; Nahm M; Schroer K; Davie J; Baker P; Kearney J; Barletta R
  • Start Page

  • 694
  • End Page

  • 705
  • Volume

  • 153
  • Issue

  • 3