A genetic locus responsible for salmonella susceptibility in BSVS mice is not responsible for the limited T-dependent immune responsiveness of BSVS mice.

Academic Article

Abstract

  • BSVS mice are known to be highly susceptible to salmonella infection. We have shown that the bulk of the difference in susceptibility between BSVS and salmonella-resistant A/J mice is the result of a genetic difference at a single locus not closely linked to H-2, Igh-C, or Hbb, and not X-linked. We have backcrossed the A/J allele at this locus into BSVS mice for 8 successive generations and have demonstrated that the salmonella resistance afforded by this allele is not the result of a restoration of the generalized poor T-dependent responsiveness of BSVS mice. The salmonella resistance locus we have examined with these 2 strains is probably the same as the Ity locus described by others.
  • Published In

    Keywords

  • Animals, Antibodies, Bacterial, Chromosome Mapping, Listeria monocytogenes, Mice, Mice, Inbred A, Mice, Inbred BALB C, Mice, Inbred C57BL, Salmonella Infections, Animal, Salmonella typhimurium, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, T-Lymphocytes
  • Author List

  • Briles DE; Benjamin WH; Williams CA; Davie JM
  • Start Page

  • 906
  • End Page

  • 911
  • Volume

  • 127
  • Issue

  • 3