Geographic Distribution of Penicillin-Resistant Clones of Streptococcus pneumoniae: Characterization by Penicillin-Binding Protein Profile, Surface Protein A Typing, and Multilocus Enzyme Analysis

Academic Article


  • Examination of several hundred penicillin-resistant clinical isolates of Streptococcus pneumoniae has revealed extensive strain-to-strain variation in the number and molecular size of penicillin-binding proteins (PBPs). This polymorphism has been used to classify resistant isolates into groups (PBP families) that share distinct electrophoretic profiles. We describe herein properties of four such PBP families: two from Spain (and/or Ohio) and one each from Hungary and Alaska. We have discovered that representative isolates assigned to each PBP family also share capsular serotype, antibiotic resistance pattern, pneumococcal surface protein A type, and multilocus enzyme genotype. The results demonstrate independent clonal origin for strains assigned to each PBP family. Each resistant clone occurs with uniquely high incidence within specific geographic areas. © 1992 by The University of Chicago.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 822255
  • Author List

  • Munoz R; Musser JM; Crain M; Briles DE; Marton A; Parkinson AJ; Sorensen U; Tomasz A
  • Start Page

  • 112
  • End Page

  • 118
  • Volume

  • 15
  • Issue

  • 1