Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children

Academic Article

Abstract

  • Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective.
  • Authors

    Pubmed Id

  • 2834390
  • Author List

  • Vela Coral MC; Fonseca N; CastaƱeda E; Di Fabio JL; Hollingshead SK; Briles DE
  • Start Page

  • 832
  • End Page

  • 836
  • Volume

  • 7
  • Issue

  • 5