Immunogenic protein contaminants in pneumococcal vaccines

Academic Article


  • Currently available pneumococcal vaccines were examined for contamination by pneumococcal surface protein A (PspA) and pneumococcal surface adhesin A (PsaA). PspA could be detected in some (but not all) lots of 23-valent polysaccharide vaccine. Many lots of pneumococcal vaccines, including the heptavalent conjugate vaccine, were found to elicit small (but variable) antibody responses to PspA, PsaA, or both. The degree of contamination was highly variable, and this should be considered in pneumococcal vaccine evaluations or when capsular polysaccharide is used for pneumococcal antibody assays.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 12529869
  • Author List

  • Yu J; Briles DE; Englund JA; Hollingshead SK; Glezen WP; Nahm MH
  • Start Page

  • 1019
  • End Page

  • 1023
  • Volume

  • 187
  • Issue

  • 6