Heat-shock protein ClpL/HSP100 increases penicillin tolerance in streptococcus pneumoniae

Academic Article


  • Penicillin resistance and tolerance has been an increasing threat to the treatment of pneumococcal pneumoniae. However, no penicillin tolerance-related genes have been claimed. Here we show that a major heat shock protein ClpL/HSP100 could modulate the expression of a cell wall synthesis enzyme PBP2x, and subsequently increase cell wall thickness and penicillin tolerance in Streptococus pneumoniae. Copyright © 2011 S. Karger AG, Basel.
  • Authors

    Digital Object Identifier (doi)

    Pubmed Id

  • 7022932
  • Author List

  • Tran TDH; Kwon HY; Kim EH; Kim KW; Briles DE; Pyo S; Rhee DK
  • Start Page

  • 126
  • End Page

  • 128
  • Volume

  • 72