The synergistic effects of HIV, diabetes, and aging on cognition: implications for practice and research.

Academic Article


  • Thanks to highly active antiretroviral therapy, many people infected with HIV will likely live into old age. Although this is a welcome prognosis, new issues are emerging that may complicate the ability to successfully age in this clinical population. HIV and aging independently are related to cognitive impairments, so there are concerns that those aging with HIV may be more at risk of such cognitive impairments. Moreover, highly active antiretroviral therapy itself can create metabolic disorders, such as prediabetes and/or frank type 2 diabetes, which have also been linked to poorer cognitive functioning. Thus, concerns increase that, as people age with HIV and develop comorbid metabolic disorders that may lead to type 2 diabetes, they will be at triple risk of developing cognitive impairments that can impair everyday functioning and reduce quality of life. This article explores these issues and provides implications for practice and research.
  • Published In


  • AIDS Dementia Complex, Adult, Aged, Antiretroviral Therapy, Highly Active, Cognition Disorders, Comorbidity, Diabetes Complications, Female, Frail Elderly, Humans, Male, Middle Aged, Neuropsychological Tests, Risk Factors
  • Digital Object Identifier (doi)

    Author List

  • Vance DE; Fazeli PL; Dodson JE; Ackerman M; Talley M; Appel SJ
  • Start Page

  • 292
  • End Page

  • 305
  • Volume

  • 46
  • Issue

  • 5