Effects of early life exposure to methylmercury in Daphnia pulex on standard and reduced food ration

Academic Article


  • As a well-known eco-toxicological model organism, Daphnia pulex may also offer advantages in human health research for assessing long-term effects of early life exposures to coupled stressors. Here, we examine consequences of early life exposure to methylmercury (MeHg) under standard and reduced food ration. We exposed Daphnia for 24. h in early life to varying concentrations of methylmercury(II) chloride (0, 200, 400, 800 and 1600. ng/L) and thereafter kept Daphnia on either a standard or a reduced food ration. The data suggests an additive effect of MeHg concentration and food ration on decreasing lifespan, although MeHg concentration does not affect survival linearly. Food ration and MeHg concentration were predictive of reduced reproduction, and there is some evidence of an interaction (p= 0.048). Multi-stressor work in alternative model systems may be useful for prioritizing research, taking into account potential antagonistic, additive or synergistic effects that nutritional status may have on chemical toxicity.
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    Digital Object Identifier (doi)

    Author List

  • Doke DA; Hudson SL; Dawson JA; Gohlke JM
  • Start Page

  • 219
  • End Page

  • 225
  • Volume

  • 49