EGFR expression in advanced head and neck cutaneous squamous cell carcinoma.

Academic Article


  • BACKGROUND: The significance of epidermal growth factor receptor (EGFR) expression in advanced cutaneous squamous cell carcinoma (SCC) of the head and neck remains poorly understood. METHODS: We performed a retrospective review of patients with advanced-stage (stage III or stage IV) cutaneous SCC of the head and neck (n = 56). RESULTS: The majority of patients (91%) had stage III disease, with 54% having regional metastasis and 9% with distant metastasis. Two-year survival was 64% and the 5-year survival was 56%. EGFR was found to be overexpressed in 56% of primary tumors and 58% of regional metastatic disease. Overall survival did not correlate with EGFR (p = .47) expression in primary lesions, nor was it associated with an increase in regional (p = .74) or distant metastasis (p = .56). Furthermore, there was no correlation between clinicopathologic characteristics and EGFR expression CONCLUSIONS: These data do not suggest upregulation of EGFR is associated with poor survival or aggressive disease.
  • Published In


  • Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, ErbB Receptors, Female, Head and Neck Neoplasms, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphatic Metastasis, Male, Middle Aged, Retrospective Studies, Skin Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Sweeny L; Dean NR; Magnuson JS; Carroll WR; Helman EE; Hyde SO; Desmond RL; Rosenthal EL
  • Start Page

  • 681
  • End Page

  • 686
  • Volume

  • 34
  • Issue

  • 5