On solid-phase antibody assays

Academic Article

Abstract

  • There is considerable evidence that pre-operative and post-operative anti-human leukocyte antigen (anti-HLA) antibodies are deleterious in thoracic transplantation. While debate continues in heart and lung transplantation on the role of and the diagnosis and treatment of antibody-mediated rejection (AMR), central to the discussion is our ability to detect anti-HLA antibodies. This perspective outlines the concerns elicited by new technology for detection of anti-HLA antibodies using solid-phase assays, and highlights the need for functional assays to further understand the clinical significance of these antibodies. © 2010 International Society for Heart and Lung Transplantation.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Pajaro OE; George JF
  • Start Page

  • 1207
  • End Page

  • 1209
  • Volume

  • 29
  • Issue

  • 11