DHEA: A novel adjunct for the treatment of male trauma patients

Academic Article

Abstract

  • Despite significant advances in the management of trauma victims, traumatic injury with the ensuing sepsis and multiple organ failure remains the leading cause of death between the ages of 18 and 44 in the USA. Recently, interest in the clinically and experimentally observed gender dimorphic response to traumatic injury has led to the possibility of modulating cell and organ functions following trauma and hemorrhagic shock by the administration of sex steroids. Here, we review the effects of the adrenal steroid dehydroepiandrosterone (DHEA), a precursor of sex steroid synthesis, on organ and immune functions following trauma-hemorrhage, and its potential as a novel therapy for improving the depressed cell and organ functions in trauma patients.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Jarrar D; Kuebler JF; Wang P; Bland KI; Chaudry IH
  • Start Page

  • 81
  • End Page

  • 85
  • Volume

  • 7
  • Issue

  • 2