13-cis-retinoic acid: Inhibition of bladder carcinogenesis induced in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

Academic Article


  • Transitional cell carcinoma was induced in the bladders of male Fischer rats by 12 oral doses of the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine. Feeding of 13-cis-retinoic acid after completion of carcinogen treatment diminished the number and severity of cancers and other proliferative lesions of the bladder.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Grubbs CJ; Moon RC; Squire RA; Farrow GM; Stinson SF; Goodman DG; Brown CC; Sporn MB
  • Start Page

  • 743
  • End Page

  • 744
  • Volume

  • 198
  • Issue

  • 4318