Pazopanib combined with radiation: in vivo model of interaction.

Academic Article

Abstract

  • OBJECTIVE: Assess interaction of pazopanib, an oral antivascular endothelial growth factor inhibitor, with radiation in tumor xenograft models. METHODS: Flank xenografts in female athymic nude mice of human lung cancer cell line, A549, and head and neck cancer cell line, UM-SCC-6, were allowed to grow to ∼5×5 mm. Groups were then treated with pazopanib and/or escalating doses of radiation and tumor measurements over time compared with untreated tumor-bearing controls. Pazopanib (100 mg/kg) began 7 days before radiation and continued for 28 days. Daily radiation was 0.5, 1, 2, or 3 Gy ×5 days. RESULTS: Tumors in the A549 control group reached >4× the original size by day 36 postradiation. All treatment groups had less robust tumor growth (p<0.05) and the group receiving pazopanib+3 Gy radiation/day had tumor regression to less than baseline. In the UM-SCC-6-tumor-bearing animals, tumors in all treatment groups had less robust growth than untreated controls after day 23 post-treatment. CONCLUSION: The combination of pazopanib and radiation resulted in a trend of superior tumor growth inhibition compared with either agent alone. All treatment groups had impaired tumor progression compared with untreated controls.
  • Keywords

  • pazopanib, radiation, xenograft tumor model, Angiogenesis Inhibitors, Animals, Cell Line, Tumor, Combined Modality Therapy, Female, Head and Neck Neoplasms, Humans, Lung Neoplasms, Mice, Mice, Nude, Pyrimidines, Sulfonamides, Xenograft Model Antitumor Assays
  • Digital Object Identifier (doi)

    Author List

  • Meredith RF; Raisch KP; Bonner JA; Buchsbaum DJ; Grizzle WE; Li Y; Spencer SA
  • Start Page

  • 247
  • End Page

  • 250
  • Volume

  • 29
  • Issue

  • 6