Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia.

Academic Article


  • Mycoplasma pneumoniae is a highly specialized parasitic bacterium that is a significant cause of community-acquired pneumonia in children. Although most such respiratory infections are mild, a minor percentage of patients require hospitalization and, occasionally, intensive treatment for respiratory failure. A variety of extrapulmonary sequelae of M pneumoniae infections have been described, including Stevens-Johnson syndrome. Macrolide resistance in M pneumoniae has developed rapidly in Asia, particularly in China, over the past decade and is now appearing in the United States. Emerging resistance to macrolides creates a therapeutic conundrum, particularly for pediatricians caring for young children in whom absolute or relative contraindications exist for the use of tetracyclines or fluoroquinolones, the 2 other main classes of drugs shown to be efficacious for M pneumoniae. We describe here the case of a child with a prolonged febrile illness associated with Stevens-Johnson-like mucocutaneous involvement who was found to have a respiratory infection with macrolide-resistant M pneumoniae.
  • Published In

  • Pediatrics  Journal
  • Keywords

  • Child, Diagnosis, Differential, Drug Resistance, Microbial, Follow-Up Studies, Humans, Macrolides, Male, Mycoplasma pneumoniae, Pneumonia, Mycoplasma, Stevens-Johnson Syndrome
  • Digital Object Identifier (doi)

    Author List

  • Atkinson TP; Boppana S; Theos A; Clements LS; Xiao L; Waites K
  • Start Page

  • e1605
  • End Page

  • e1609
  • Volume

  • 127
  • Issue

  • 6