Fasting and postprandial markers of inflammation in lean and overweight children.

Academic Article


  • BACKGROUND: Overweight children have greater circulating concentrations of markers of inflammation (MOI) than do lean children. Whether adiposity influences the postprandial MOI response is unknown. OBJECTIVE: We aimed to evaluate the relations of fasting and postprandial MOI with total and regional adiposity and insulin sensitivity in children. DESIGN: Fifty-nine children aged 7-12 y were assessed for C-reactive protein (CRP), interleukin-6 (IL-6), and soluble tumor necrosis factor receptor-2 (sTNF-R2) in the fasted state and after a mixed meal. Insulin sensitivity, body composition, and abdominal adipose tissue distribution were assessed with a frequently sampled intravenous-glucose-tolerance test, dual-energy X-ray absorptiometry, and computed tomography, respectively. RESULTS: Central adipose measures were not independently associated with fasting MOI, although they were independently inversely associated with the postprandial sTNF-R2 response (r = -0.30 to -0.37, P = 0.02-0.006). The inverse association between intraabdominal adipose tissue and the postprandial CRP response was nearly significant (r = -0.27, P = 0.05). Insulin sensitivity was not associated with fasting or postprandial CRP or sTNF-R2; however, there was a positive relation between insulin sensitivity and fasting IL-6 (r = 0.27, P = 0.03), which was attenuated after adjustment for lean body mass (r = 0.25, P = 0.08). CONCLUSIONS: Excess adiposity is associated with both fasting and postprandial MOI. The postprandial MOI response may be influenced by central adiposity in children. The positive association of insulin sensitivity with IL-6 warrants further study.
  • Keywords

  • Abdominal Fat, Biomarkers, Body Composition, C-Reactive Protein, Child, Cross-Sectional Studies, Fasting, Female, Glucose Tolerance Test, Humans, Inflammation, Insulin, Interleukin-6, Male, Overweight, Postprandial Period, Receptors, Tumor Necrosis Factor, Type II, Thinness
  • Digital Object Identifier (doi)

    Author List

  • Alvarez JA; Higgins PB; Oster RA; Fernandez JR; Darnell BE; Gower BA
  • Start Page

  • 1138
  • End Page

  • 1144
  • Volume

  • 89
  • Issue

  • 4