Determination of Gangliosides in Six Human Primary Medulloblastomas

Academic Article

Abstract

  • Abstract: The ganglioside composition of six human medulloblastomas was analyzed. The characterization was performed by thin‐layer chromatography, sialidase hydrolysis, and immunological staining with a panel of characterized antiganglioside monoclonal antibodies. The total ganglioside content ranged from 60 to 1,130 nmol of ganglioside sialic acid/g wet weight. Neuronal gangliosides (gangliotetraose series) were found in varying amounts in all medulloblastomas. Gangliosides of the neolactotetraose series (3′‐LM 1 and LD1) were present in all specimens, and the lactotetraose series ganglioside 3′‐isoLM1 was found in all cases showing astro‐cytic differentiation. This supports our previous findings that 3′‐isoLM1 is a marker for proliferating astroglial cells. Copyright © 1990, Wiley Blackwell. All rights reserved
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    Digital Object Identifier (doi)

    Author List

  • Gottfries J; Fredman P; Mansson J; Collins VP; von Hoist H; Armstrong DD; Percy AK; Wikstrand CJ; Bigner DD; Svennerholm L
  • Start Page

  • 1322
  • End Page

  • 1326
  • Volume

  • 55
  • Issue

  • 4