Neonatal herpes simplex virus infections.

Academic Article


  • Neonatal herpes simplex virus infections are uncommon, but because of the morbidity and mortality associated with the infection they are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction for diagnosis of central nervous system infections and the development of safe and effective antiviral therapy has revolutionized the diagnosis and management of these infants. Initiation of long-term antiviral suppressive therapy in these infants has led to significant improvement in morbidity. This article summarizes the epidemiology of neonatal herpes simplex virus infections and discusses clinical presentation, diagnosis, management, and follow up of infants with neonatal herpes disease.
  • Published In


  • Acyclovir, Adult, Antiviral Agents, Central Nervous System Viral Diseases, Developmental Disabilities, Diagnosis, Differential, Evidence-Based Medicine, Female, Herpes Genitalis, Herpes Simplex, Herpes Simplex Virus Vaccines, Humans, Infant, Newborn, Morbidity, Mothers, Polymerase Chain Reaction, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Infectious, Prognosis, Recurrence, Risk Factors, Severity of Illness Index, Simplexvirus
  • Digital Object Identifier (doi)

    Author List

  • Pinninti SG; Kimberlin DW
  • Start Page

  • 351
  • End Page

  • 365
  • Volume

  • 60
  • Issue

  • 2