Cytomegalovirus blood viral load and hearing loss in young children with congenital infection.

Academic Article

Abstract

  • BACKGROUND: This study was designed to determine whether elevated viral load in infants and young children is associated with congenital cytomegalovirus (CMV)-related hearing loss. METHODS: Blood samples were obtained from 135 children with congenital CMV infection. CMV DNA in the peripheral blood was quantitated with a real-time polymerase chain reaction assay. Viral load measurements were analyzed in 3 different age groups (<2 months, 2-12 months, 12-36 months). RESULTS: In children with symptomatic and asymptomatic infection, CMV DNA levels were not different between children with hearing deficit and those with normal hearing in all 3 age groups. In children with asymptomatic infection, the positive predictive value of a peripheral blood viral load >3500 genomic equivalents per milliliter (ge/mL) at <2 months and 2 to 12 months of age is 8%, and at 12 to 36 months of age is 11.8%. However, the negative predictive value of a viral load <3500 ge/mL is 94.4% at <2 months of age, and 100% at 2 to 36 months of age. CONCLUSIONS: Peripheral blood viral load is not associated with hearing loss in children with congenital CMV infection. However, a viral load of <3500 ge/mL is associated with a lower risk of hearing loss in children born with asymptomatic congenital infection.
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    Keywords

  • Child, Preschool, Cytomegalovirus, Cytomegalovirus Infections, DNA, Viral, Female, Hearing Loss, Humans, Infant, Infant, Newborn, Male, Polymerase Chain Reaction, Predictive Value of Tests, Risk Factors, Viral Load
  • Digital Object Identifier (doi)

    Authorlist

  • Ross SA; Novak Z; Fowler KB; Arora N; Britt WJ; Boppana SB
  • Start Page

  • 588
  • End Page

  • 592
  • Volume

  • 28
  • Issue

  • 7