Outcomes of Stage I/II vulvar cancer patients after negative superficial inguinal lymphadenectomy.

Academic Article

Abstract

  • OBJECTIVES: To investigate the patterns of recurrence associated with superficial inguinal lymphadenectomy (SupIL) and vulvectomy for patients with Stage I/II vulvar cancer. METHODS: A retrospective chart review identified patients from 1990-2001 with Stage I/II vulvar cancer that underwent SupIL and vulvectomy. Survival was analyzed using the Kaplan-Meier method with Fisher Exact and Chi-square tests for comparisons between groups. RESULTS: 65 patients with Stage I/II vulvar cancer with a pathologically negative SupIL were identified (30 Stage I, 35 Stage II). Three patients recurred in the inguinal region, (4.6%) and 11 patients (16.9%) recurred on the vulva. Two of the 11 patients died of disease, six patients are alive without evidence of disease after additional therapy. Five-year disease-free survival and overall survival were 66% and 97%, respectively. Risk of recurrence was not associated with smoking status, stage, or margin status. CONCLUSIONS: SupIL and vulvectomy for Stage I/II vulvar cancer have a low recurrence rate in the inguinal region when nodes are negative. The local recurrence rate (17%) is acceptable, and overall survival is good using this conservative approach.
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    Keywords

  • Adult, Aged, Aged, 80 and over, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Risk Factors, Treatment Outcome, Vulvar Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Kirby TO; Rocconi RP; Numnum TM; Kendrick JE; Wright J; Fowler W; Mutch DG; Bhoola SM; Huh WK; Straughn JM
  • Start Page

  • 309
  • End Page

  • 312
  • Volume

  • 98
  • Issue

  • 2