Efficacy and safety of imatinib mesylate (Gleevec®) and immunohistochemical expression of c-Kit and PDGFR-β in a Gynecologic Oncology Group Phase Il Trial in women with recurrent or persistent carcinosarcomas of the uterus

Academic Article

Abstract

  • Purpose.: This multi-institutional phase II trial assessed the activity and toxicity of imatinib mesylate and explored c-Kit and platelet-derived growth factor receptor (PDGFR)-β in recurrent or persistent uterine carcinosarcoma. Methods.: Women with measurable uterine carcinosarcoma, who had a performance status of 0, 1, or 2 and had received up to two prior treatment regimens, were eligible and treated with a 600-mg daily oral dose of imatinib mesylate until disease progression or unacceptable toxicity. Endpoints included progression-free survival (PFS) ≥ 6 months, overall toxicity, PFS, overall survival (OS), and response. c-Kit and PDGFR-β were evaluated by immunohistochemistry in archival tumor. Results.: Twenty-six women were enrolled, 23 were eligible/evaluable, 1 was ineligible (wrong primary), and 2 were inevaluable (never treated). One subject had a PFS time ≥ 6 months, yielding the only patient with stable disease. All other patients had progressive disease (n = 17) or were inevaluable for tumor response (n = 5). Adverse events included grade 4 hypocalcemia (n = 1) and grade 3 fatigue, dehydration and anorexia, genitourinary/renal, lymphatic, metabolic, and ocular toxicity (n = 1 each, 4%). Positive expression of c-Kit or PDGFR-β was observed in 88% (14/16) or 40% (6/15) and in 56% (9/16) or 73% (11/15) of cases in the sarcoma and carcinoma component of the tumor, respectively. Expression of c-Kit in the carcinoma component appeared to be associated with worse OS. No other associations were notable. Conclusion.: Imatinib mesylate was generally well tolerated but had minimal activity as a single agent in unscreened patients. The potential association between carcinomatous c-Kit and OS requires validation. © 2010 Elsevier Inc. All rights reserved.
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    Author List

  • Huh WK; Sill MW; Darcy KM; Elias KM; Hoffman JS; Boggess JF; Alvarez RD; Long HJ; O'Malley DM; Birrer MJ
  • Start Page

  • 248
  • End Page

  • 254
  • Volume

  • 117
  • Issue

  • 2