Black race independently predicts worse survival in uterine carcinosarcoma.

Academic Article

Abstract

  • OBJECTIVE: GOG 150 suggested that Black women had worse survival compared to White women with uterine carcinosarcoma. Our objective was to compare treatment and survival outcomes between Black and White women at a National Comprehensive Cancer Network (NCCN) cancer center serving a diverse racial population. METHODS: An IRB approved retrospective cohort study of uterine carcinosarcoma patients diagnosed between 2000 and 2012 was performed. Survival was compared by race and stratified by stage. Median progression free and overall survival (PFS and OS) were calculated using Kaplan-Meier estimates and compared with the log-rank test. Multivariate survival analysis was performed with Cox proportional hazards model. RESULTS: 158 women were included: 93 (59%) were Black and 65 (41%) were White. 95 (60%) had early stage disease and 63 (40%) had advanced stage disease. Black women had a shorter PFS (7.9 vs. 14.2 months, p<0.001) and OS (13.4 vs. 30.8 months, p<0.001). There was no difference in survival between Black and White women with advanced stage disease (OS 8.5 vs. 11.8, p=0.18). However, PFS and OS were worse in Black women compared to White women with early stage disease (PFS 13.6 vs. 77.4, p=0.001), (OS 25.4 vs. 94.7, p=0.003). On multivariate analysis accounting for age, stage, BMI, and adjuvant treatment, Black race remained independently associated with risk of death (HR 2.0; 95% CI 1.25-3.23). CONCLUSIONS: Black women with uterine carcinosarcoma have worse survival compared to White women despite similar patient and treatment characteristics. This difference is largely due to differences in survival in early stage disease.
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    Keywords

  • Adjuvant treatment, Racial disparities, Uterine carcinosarcoma, African Americans, Aged, Cancer Care Facilities, Carcinosarcoma, Chemotherapy, Adjuvant, Cohort Studies, Disease-Free Survival, European Continental Ancestry Group, Female, Humans, Hysterectomy, Kaplan-Meier Estimate, Lymph Node Excision, Middle Aged, Multivariate Analysis, Neoplasm, Residual, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, Retrospective Studies, Treatment Outcome, Uterine Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Erickson BK; Doo DW; Zhang B; Huh WK; Leath CA
  • Start Page

  • 238
  • End Page

  • 241
  • Volume

  • 133
  • Issue

  • 2