Treatment of primary CNS lymphoma with high-dose methotrexate in immunocompetent pediatric patients.

Academic Article

Abstract

  • We report two cases of primary CNS lymphoma (PCNSL) treated with high-dose methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patients. Studies in adults indicate methotrexate therapy can be effective against PCNSL and has advantages over the current standard of treatment. Both patients have no evidence of disease 9 and 7 years after treatment, suggesting high-dose methotrexate may lead to disease control in pediatric patients with PCNSL while avoiding the effects of radiotherapy.
  • Published In

    Keywords

  • Adolescent, Antimetabolites, Antineoplastic, Central Nervous System Neoplasms, Dose-Response Relationship, Drug, Female, Humans, Immunocompetence, Infant, Lymphoma, B-Cell, Lymphoma, Large-Cell, Anaplastic, Male, Methotrexate, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Shah AC; Kelly DR; Nabors LB; Oakes WJ; Hilliard LM; Reddy AT
  • Start Page

  • 1227
  • End Page

  • 1230
  • Volume

  • 55
  • Issue

  • 6