Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat

Academic Article

Abstract

  • Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with the human sequence. Northern blot analysis detects a single transcript of approximately 1.5 kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No mutations were identified in the coding region of the gene in the genetically dystonic (dt) rat. © 2002 Elsevier Science B.V. All rights reserved.
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    Author List

  • Ziefer P; Leung J; Razzano T; Shalish C; LeDoux MS; Lorden JF; Ozelius L; Breakefield XO; Standaert DG; Augood SJ
  • Start Page

  • 132
  • End Page

  • 135
  • Volume

  • 101
  • Issue

  • 1-2