Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat.

Academic Article


  • Deletions within the TOR1A gene cause early-onset (DYT1) torsion dystonia. We have cloned and sequenced the rat cDNA homologue of TOR1A and found a 91% identity with the human sequence. Northern blot analysis detects a single transcript of approximately 1.5 kb. In situ hybridization reveals a widespread distribution of torsinA mRNA within brain. No mutations were identified in the coding region of the gene in the genetically dystonic (dt) rat.
  • Published In

  • Brain Research  Journal
  • Keywords

  • Animals, Brain, Carrier Proteins, Cloning, Molecular, Disease Models, Animal, Dystonia Musculorum Deformans, Gene Expression, Humans, Mice, Molecular Chaperones, Molecular Sequence Data, Mutation, Neurons, RNA, Messenger, Rats, Rats, Mutant Strains, Rats, Sprague-Dawley, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid
  • Author List

  • Ziefer P; Leung J; Razzano T; Shalish C; LeDoux MS; Lorden JF; Ozelius L; Breakefield XO; Standaert DG; Augood SJ
  • Start Page

  • 132
  • End Page

  • 135
  • Volume

  • 101
  • Issue

  • 1-2