Dopamine transmission in DYT1 dystonia: A biochemical and autoradiographical study

Academic Article

Abstract

  • Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D1, receptor and D2 receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.
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    Author List

  • Augood SJ; Hollingsworth Z; Albers DS; Yang L; Leung JC; Muller B; Klein C; Breakefield XO; Standaert DG
  • Start Page

  • 445
  • End Page

  • 448
  • Volume

  • 59
  • Issue

  • 3