Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study.

Academic Article

Abstract

  • Indices of dopamine transmission were measured in the postmortem striatum of DYT1 dystonia brains. A significant increase in the striatal 3,4-dihydroxyphenylacetic acid/dopamine ratio was found. Quantitative autoradiography revealed no differences in the density of dopamine transporter or vesicular monoamine transporter-2 binding; however, there was a trend toward a reduction in D(1) receptor and D(2) receptor binding. One brain with DYT1 parkinsonism was similarly evaluated and marked reductions in striatal dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid content as well as the density of binding of all four dopaminergic ligands were measured.
  • Published In

  • Neurology  Journal
  • Keywords

  • Autoradiography, Carrier Proteins, Corpus Striatum, Dopamine, Dopamine Plasma Membrane Transport Proteins, Dystonia Musculorum Deformans, Humans, Membrane Glycoproteins, Membrane Transport Proteins, Middle Aged, Molecular Chaperones, Nerve Tissue Proteins, Neuropeptides, Receptors, Dopamine, Vesicular Biogenic Amine Transport Proteins, Vesicular Monoamine Transport Proteins
  • Author List

  • Augood SJ; Hollingsworth Z; Albers DS; Yang L; Leung J-C; Muller B; Klein C; Breakefield XO; Standaert DG
  • Start Page

  • 445
  • End Page

  • 448
  • Volume

  • 59
  • Issue

  • 3