Incidence of hip osteonecrosis among renal transplantation recipients: a prospective study.

Academic Article


  • AIM: To investigate whether a lessened glucocorticoid cumulative dose would lead to a decreased incidence of femoral head osteonecrosis. METHODS: Newly transplanted in-patients (n = 49) underwent hip radiographs and magnetic resonance imaging (MRI) a mean of 17.0+/-4.3 (range 8-29) days after renal transplantation. For the 48 patients without evidence of prevalent osteonecrosis, imaging at a mean of 5.9+/-0.8 (range 4.8-8.7) months after renal transplantation was graded for presence/absence of femoral head osteonecrosis by two blinded radiologists. Sociodemographic and disease characteristics of patients were compared to identify potential associations with incident osteonecrosis. RESULTS: At 6-month follow-up, only two patients (4%) had osteonecrosis of the femoral head (three hips). The two primary radiologists had excellent agreement between osteonecrosis diagnosis (kappa coefficient=0.78). Both cases of a definite MRI diagnosis of osteonecrosis occurred in patients who were in the highest tertile of glucocorticoid dosage. CONCLUSION: Osteonecrosis was uncommon among a prospective cohort of renal transplant recipients within 6 months after engraftment.
  • Published In

  • Clinical Radiology  Journal
  • Keywords

  • Cohort Studies, Female, Femur Head Necrosis, Hip Joint, Humans, Kidney Transplantation, Magnetic Resonance Imaging, Male, Middle Aged, Osteonecrosis, Prospective Studies, Tomography, X-Ray Computed
  • Digital Object Identifier (doi)

    Author List

  • Lopez-Ben R; Mikuls TR; Moore DS; Julian BA; Bernreuter WK; Elkins M; Saag KG
  • Start Page

  • 431
  • End Page

  • 438
  • Volume

  • 59
  • Issue

  • 5