From bone biology to clinical outcome: state of the art and future perspectives.

Academic Article

Abstract

  • In the last decade progress has been made in our understanding of bone biology. In particular, the relation between inflammation and bone has become much clearer, leading to bone-targeting therapies in inflammatory rheumatic diseases. The clinical sequelae of the influences of both inflammation and immobility (due to arthritis) on bone for different rheumatic diseases (such as rheumatoid arthritis, systemic lupus erythematosus and spondyloarthritides) have also now captured the attention of clinicians. In the last decade the well-known negative influences of glucocorticoids on bone have become more treatable as a result of new drugs that stimulate osteoblasts and restore the negative bone balance.
  • Authors

    Published In

    Keywords

  • Arthritis, Rheumatoid, Bone Remodeling, Glucocorticoids, Humans, Inflammation, Osteoporosis, Practice Guidelines as Topic, Rheumatic Diseases, Rheumatology
  • Digital Object Identifier (doi)

    Author List

  • Schett G; Saag KG; Bijlsma JWJ
  • Start Page

  • 1415
  • End Page

  • 1419
  • Volume

  • 69
  • Issue

  • 8