IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung

Academic Article

Abstract

  • IL-23 is required for the IL-17 response to infection with Mycobacterium tuberculosis, but is not required for the early control of bacterial growth. However, mice deficient for the p19 component of IL-23 (Il23a -/-) exhibit increased bacterial growth late in infection that is temporally associated with smaller B cell follicles in the lungs. Cxcl13 is required for B cell follicle formation and immunity during tuberculosis. The absence of IL-23 results in decreased expression of Cxcl13 within M. tuberculosisinduced lymphocyte follicles in the lungs, and this deficiency was associated with increased cuffing of T cells around the vessels in the lungs of these mice. Il23a -/- mice also poorly expressed IL-17A and IL-22 mRNA. These cytokines were able to induce Cxcl13 in mouse primary lung fibroblasts, suggesting that these cytokines are likely involved in B cell follicle formation. Indeed, IL-17RA-deficient mice generated smaller B cell follicles early in the response, whereas IL-22-deficient mice had smaller B cell follicles at an intermediate time postinfection; however, only Il23a -/- mice had a sustained deficiency in B cell follicle formation and reduced immunity.We propose that in the absence of IL-23, expression of long-term immunity to tuberculosis is compromised due to reduced expression of Cxcl13 in B cell follicles and reduced ability of T cells to migrate from the vessels and into the lesion. Further, although IL-17 and IL-22 can both contribute to Cxcl13 production and B cell follicle formation, it is IL-23 that is critical in this regard. Copyright © 2011 by The American Association of Immunologists, Inc.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9920908
  • Author List

  • Khader SA; Guglani L; Rangel-Moreno J; Gopal R; Fallert Junecko BA; Fountain JJ; Martino C; Pearl JE; Tighe M; Lin YY
  • Start Page

  • 5402
  • End Page

  • 5407
  • Volume

  • 187
  • Issue

  • 10