BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model.

Academic Article

Abstract

  • To develop a better animal model for studying the effects of the host environment in neoplasia, we injected various genetically well-characterized H-2(d) RI strains of BXD mice with syngeneic breast cancer cells (TS/A) and monitored the growth of tumors over time. There was a marked difference in the growth of the implanted breast cancer cells among the 14 BXD RI strains, with 4 patterns of tumor development being observed: in type I, the implanted tumor cells grew rapidly in the first 2 weeks, necrosis of the tumors was observed and metastases to the intestinal lymph nodes and pancreas was observed, causing death; in type II, the implanted tumor cells grew slowly and attained a size after day 50 that required killing the animal, with tumor necrosis being rare and metastases absent; in type III, the implanted tumor cells grew initially but underwent a slow decline after 4 weeks; and in type IV, the implanted tumor cells failed to develop. Apoptosis of the implanted tumor cells was responsible for the regression of tumor nodules. The T-cell immune response minimized tumor development in types III and IV since T-cell depletion of the BXD RI mice resulted in aggressively growing tumors in these strains.
  • Published In

    Keywords

  • Animals, Breast Neoplasms, Disease Models, Animal, Female, Genetic Predisposition to Disease, Immunity, Cellular, Immunophenotyping, Lymph Nodes, Major Histocompatibility Complex, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Neoplasm Transplantation, T-Lymphocytes, Transplantation, Isogeneic, Tumor Cells, Cultured
  • Digital Object Identifier (doi)

    Author List

  • Grizzle WE; Mountz JD; Yang P-A; Xu X; Sun S; Van Zant GE; Williams RW; Hsu H-C; Zhang H-G
  • Start Page

  • 270
  • End Page

  • 279
  • Volume

  • 101
  • Issue

  • 3