Treatment of Lupus Nephritis with Combined Therapy

Academic Article


  • To the Editor: The report of Donadio and his associates on the treatment of diffuse proliferative lupus nephritis1 contains a point of confusion centering on the use of the terms “clinical flare-up” (or “recurrence”) and “progression” and the implications of this usage regarding the temporary or permanent nature of the observed clinical phenomena. A clinical flare-up, as defined, has no requirement for permanent deterioration, and indeed 84 per cent of patients with such a flareup defined at entry into the study showed subsequent improvement at six-month follow-up examination. In contrast, “progression“ is used in the context of continuing deterioration … progression. © 1979, Massachusetts Medical Society. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Kimberly RP; Donadio JV; Holley KE; Ferguson RH; Ilstrup DM
  • Start Page

  • 564
  • End Page

  • 565
  • Volume

  • 300
  • Issue

  • 10